Disclaimer: I am not a doctor. I don’t even play one on TV. I barely passed high school science. This is just what I’ve observed over the last 15 years in the wine industry and by doing a bit of research on the causes of wine headaches.
Why do some wines give me a headache?
One question I always get on our wine tours from guests is, “Why do I get a headache from drinking wine?” Different people get headaches from wine for different reasons. Different strokes for different folks. There is no one size fits all answer. It’ll require a little bit of investigation and trial and error on your part to figure out the cause of wine headaches.
1. Dehydration is a Major Cause of Wine Headaches
The first place to look is at your bottle. Is it empty? Well, then it’s safe to assume it was the alcohol that caused your pain. Alcohol dehydrates the body and dehydration leads to headaches. Easy fix: drink a glass of water with every glass of wine. This should keep you hydrated and keep your wine headache at bay.

2. Are sulfites the cause of wine headaches?
Also on the bottle is this warning. CONTAINS SULFITES. A-ha! That must be it! Sulfites rank first in scape-goating the headache cause. A fair assumption since it’s the only thing on the label that has a warning. Okay, so if there’s a warning they must be bad. They’re not. Some sulfites occur naturally during winemaking. Sulfites kill bacteria which keeps your wine safe from becoming vinegar. There is a legal limit to how many sulfites can be added to the wine. Generally there’s more sulfites in white wine than in red so that myth is busted if only red wine causes headaches.

Very few people are actually allergic to sulfites. While I would never suggest a no-sulfite wine (it’s likely spoiled), opt for small production wines that are organic or biodynamic. They have a lower limit for sulfites and generally are more hands off with their wines. Mass produced wines are pushing all the limits with sulfites to keep the wines alive for as long as possible. A trick to see if it’s sulfites is by eating dried fruit. There are ten times more sulfites in dried fruit than in red wine. If you can safely eat that, then it’s probably not sulfites.
Still getting a headache? Let’s delve deeper.

3. Do Tannins Cause Wine Headaches?
Bottle still full? It could be tannins. Tannin is a word we don’t come across in our everyday life so it’s natural to assume it’s this weird thing in wine that is the culprit. So far, there is no definitive link between headaches and tannins in wine. Tannins are actually good for you.
Tannins contain antioxidants that are heart healthy. Tannins are found in tea, coffee, bitter chocolate, and a lot of other bitter foods we eat. But, they also contain flavonoids which in rare cases causes serotonin levels to rise and trigger a headache. If only high tannin wines consistently give you a wine headache then that could be it for you. Easy fix: opt for wines that are lower in tannins like wines from Beaujolais (wines in France are referred to by region, Beaujolais is the made from the grape Gamay), or grape varieties like Pinot Noir and Cinsault.
4. Histamines can cause wine headaches, too
Another suspect is histamines. Histamines are found in lots of foods but also in red wine. Red wine goes through malolactic fermentation, or MLF. Malolactic fermentation converts malic acid into lactic acid and lactic acid has high levels of histamines. Red wine contains way more histamines than white wine or rose, which do not go through MLF. Histamine reactions so severe they lead to headaches are rare. The only way to avoid them is by avoiding red wine entirely. Boo! Hiss! There are some lower histamine red wines but it’s not consistent by variety or by region so there’s no guarantee. Again, try the dried fruit test. Dried fruit is also loaded with histamines. If you can safely eat dried fruits, then it’s probably not histamine either.

A perfect storm
There are other factors to consider. Are you prone to headaches and migraines already? Is there a parallel between when you’re drinking red wine to these other factors? For example, do you reach for a glass of red when you’re stressed? Or is a storm rolling in and you’ve cozied up with a book and a glass of Zin? It may be worth looking into any external factors that cause wine headaches.
Wine headaches suck. Hopefully you now have some tools to better understand what is causing yours and how to avoid one.
Frequently Asked Questions
How do you get rid of wine headaches?
Why does cheap wine give me a headache?
Does white wine cause headaches?
